Safety must be a top priority. That is why the government made various an Acts that gave authority to the Food and Drug Administration to make food, drugs, vaccines and biologics, cosmetics and medical device regulation. In the aim of fulfilling the task, the Food and Drug Administration made seven (7) main centers and one of which is the Center for Drug Evaluation and Research. The Center for Drug Evaluation and Research or commonly known as CDER has the key responsibility in regulating drugs available in the market. The center must make sure that safe and effective drugs are available so that human health is protected. Because CDER is under the Food and Drug Administration, CDER performs its task on over-the-counter and prescription drugs, including biological therapeutics and generic drugs. The Pure Food and Drugs Act (PFD Act) is the Act that gave the authority to Food and Drug Administration to regulate drugs circulating the market.